Ontology highlight
ABSTRACT:
SUBMITTER: Hofmann NA
PROVIDER: S-EPMC3436890 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Hofmann Nicole A NA Ortner Anna A Jacamo Rodrigo O RO Reinisch Andreas A Schallmoser Katharina K Rohban Rokhsareh R Etchart Nathalie N Fruehwirth Margareta M Beham-Schmid Christine C Andreeff Michael M Strunk Dirk D
PloS one 20120907 9
Despite insights into the molecular pathways regulating hypoxia-induced gene expression, it is not known which cell types accomplish oxygen sensing during neo-vasculogenesis. We have developed a humanized mouse model of endothelial and mesenchymal progenitor co-transplantation to delineate the cellular compartments responsible for hypoxia response during vasculogenesis. Mesenchymal stem/progenitor cells (MSPCs) accumulated nuclear hypoxia-inducible transcription factor (HIF)-1α earlier and more ...[more]