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Serine protease inhibition by a silanediol peptidomimetic.

ABSTRACT: Silanediol peptidomimetics are demonstrated to inhibit a serine protease. Asymmetric synthesis of the inhibitor was accomplished using Brown hydroboration and CBS reduction of an acylsilane intermediate. The silanediol product was found to inhibit the serine protease chymotrypsin with a K(i) of 107 nM. Inhibition of the enzyme may involve exchange of a silane hydroxyl with the active site serine nucleophile, contrasting with previous silanediol protease inhibitors.

SUBMITTER: Singh S

PROVIDER: S-EPMC3437013 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Serine protease inhibition by a silanediol peptidomimetic.

Singh Swapnil S Sieburth Scott McN SM

Organic letters 20120816 17

Silanediol peptidomimetics are demonstrated to inhibit a serine protease. Asymmetric synthesis of the inhibitor was accomplished using Brown hydroboration and CBS reduction of an acylsilane intermediate. The silanediol product was found to inhibit the serine protease chymotrypsin with a K(i) of 107 nM. Inhibition of the enzyme may involve exchange of a silane hydroxyl with the active site serine nucleophile, contrasting with previous silanediol protease inhibitors. ...[more]

PMID: 22894760

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