Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36.

ABSTRACT:

Background

Obsessive-compulsive disorder (OCD) has a complex etiology involving both genetic and environmental factors. However, the genetic causes of OCD are largely unknown, despite the identification of several promising candidate genes and linkage regions.

Methods

Our objective was to conduct genetic linkage studies of the type of OCD thought to have the strongest genetic etiology (i.e., childhood-onset OCD), in 33 Caucasian families with ≥2 childhood-onset OCD-affected individuals from the United States (n = 245 individuals with genotype data). Parametric and nonparametric genome-wide linkage analyses were conducted with Morgan and Merlin in these families using a selected panel of single nucleotide repeat polymorphisms from the Illumina 610-Quad Bead Chip. The initial

SUBMITTER: Mathews CA 

PROVIDER: S-EPMC3437244 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature