Experience-dependent regulation of NG2 progenitors in the developing barrel cortex.
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ABSTRACT:
SUBMITTER: Mangin JM
PROVIDER: S-EPMC3437334 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
Experience-dependent regulation of NG2 progenitors in the developing barrel cortex.
Mangin Jean-Marie JM Li Peijun P Scafidi Joseph J Gallo Vittorio V
Nature neuroscience 20120812 9
We found that, during the formation of the mouse barrel cortex, NG2 cells received glutamatergic synapses from thalamocortical fibers and preferentially accumulated along septa separating the barrels. Sensory deprivation reduced thalamocortical inputs on NG2 cells and increased their proliferation, leading to a more uniform distribution in the deprived barrels. Thus, early sensory experience regulates thalamocortical innervation on NG2 cells, as well as their proliferation and distribution durin ...[more]
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