Ontology highlight
ABSTRACT:
SUBMITTER: Cansizoglu AE
PROVIDER: S-EPMC3437625 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Cansizoglu Ahmet E AE Chook Yuh Min YM
Structure (London, England : 1993) 20071101 11
Karyopherinbeta2 (Kap beta2) or transportin imports numerous RNA binding proteins into the nucleus. Kap beta2 binds substrates in the cytoplasm and targets them through the nuclear pore complex, where RanGTP dissociates them in the nucleus. Here we report the 3.0 A crystal structure of unliganded Kap beta2, which consists of a superhelix of 20 HEAT repeats. Together with previously reported structures of NLS and Ran complexes, this structure provides understanding of conformational heterogeneity ...[more]