Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling.
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ABSTRACT:
SUBMITTER: Segerdahl AR
PROVIDER: S-EPMC3438450 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling.
Segerdahl Andrew R AR Xie Jingyi J Paterson Kathryn K Ramirez Juan D JD Tracey Irene I Bennett David L H DLH
Pain 20120224 5
We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na(v)1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain-af ...[more]
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Project description:[This corrects the article DOI: 10.1371/journal.pone.0250504.].
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