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MiR-196a2 polymorphisms and susceptibility to cancer: A meta-analysis involving 24,697 subjects.

ABSTRACT: An increasing number of studies have shown that the hsa-miR-196a2 rs11614913 polymorphism occurs in different types of cancer, but the results are generally controversial and inadequate, mainly due to limited statistical power. To resolve this issue, the present meta-analysis was carried out. Databases, including PubMed and Embase, were searched using: (miR-196a2[All Fields] OR rs11614913[All Fields]) AND ('neoplasms'[MeSH Terms] OR 'neoplasms'[All Fields] OR 'cancer'[All Fields]). Crude odds ratios (ORs) with 95% confidence intervals (CIs) were summarized in forest plots and detailed in tables. A total of 20 studies, including 11,004 cases and 13,693 controls, were included in the meta-analysis. The hsa-miR-196a2 rs11614913 polymorphism was significantly associated with an increased cancer risk in all genetic models (CC vs. TT: OR=1.280, 95% CI 1.131-1.449, P<0.001; CT vs. TT: OR=1.187, 95% CI 1.079-1.306, P<0.001; CC/CT vs. TT: OR=1.216, 95% CI 1.104-1.341, P<0.001; and CC vs. CT/TT: OR=1.115, 95% CI 1.025-1.213, P=0.011). In conclusion, this meta-analysis provides compelling evidence that the hsa-miR-196a2 rs11614913 polymorphism plays a crucial role in the development of cancer. Screening of patients for the hsa-miR-196a2 rs11614913 polymorphism can prove clinically useful for the prediction and prevention of cancer.

SUBMITTER: Wang P

PROVIDER: S-EPMC3438593 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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miR-196a2 polymorphisms and susceptibility to cancer: A meta-analysis involving 24,697 subjects.

Wang Pingyu P Xie Shuyang S Cui Aidong A Zhang Yanxiang Y Jiang Baofa B

Experimental and therapeutic medicine 20111201 2

An increasing number of studies have shown that the hsa-miR-196a2 rs11614913 polymorphism occurs in different types of cancer, but the results are generally controversial and inadequate, mainly due to limited statistical power. To resolve this issue, the present meta-analysis was carried out. Databases, including PubMed and Embase, were searched using: (miR-196a2[All Fields] OR rs11614913[All Fields]) AND ('neoplasms'[MeSH Terms] OR 'neoplasms'[All Fields] OR 'cancer'[All Fields]). Crude odds ra ...[more]

PMID: 22969890

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Project description:BackgroundMicroRNAs regulate gene expression at the post-transcriptional level and involved in diverse biological and pathological processes, including tumorigenesis. Rs11614913 in miR-196a2 and rs2910164 in miR-146a are shown to associate with increased/decreased cancer risk. We performed a meta-analysis to systematically summarize the possible association.Methodology/principal findingsWe assessed published studies of the association between these microRNA polymorphisms and cancer risk from eleven studies with 16,771 subjects for miR-196a2 and from ten studies with 15,126 subjects for miR-146a. As for rs11614913, the contrast of homozygote (TT vs CC: OR = 0.92, 95% CI = 0.85-0.99, P(heterogeneity) = 0.45), allele (T vs C: OR = 0.96, 95% CI = 0.92-0.99, P(heterogeneity) = 0.61) and recessive model (OR = 0.90, 95% CI = 0.84-0.97, P(heterogeneity) = 0.50) produced statistically association. Subgroup analysis by ethnicity, statistically significantly decreased cancer risks were found among Asians for allele contrast (OR = 0.95, 95% CI = 0.90-0.99, P(heterogeneity) = 0.74) and the recessive genetic model (OR = 0.90, 95% CI = 0.82-0.98, P(heterogeneity) = 0.85). According to subgroup analysis by tumor types, the protective effect of C/T polymorphism was only found in breast cancer under allele contrast (T vs C: OR = 0.94, 95% CI = 0.88-0.99, P(heterogeneity) = 0.26). For rs2910164, no significant associations were found among overall analysis model with relatively large heterogeneity. Through the stratified analysis, heterogeneity decreased significantly. In the subgroup analyses by cancer types, the C allele of rs2910164 was associated with protection from digestive cancer in allele contrast (C vs G: OR = 0.86, 95% CI = 0.77-0.96, P(heterogeneity) = 0.51).Conclusions/significanceOur meta-analysis suggests that the rs11614913 most likely contributes to decreased susceptibility to cancer, especially in Asians and breast cancer. Besides, the C allele of the rs2910164 might be associated with a protection from digestive cancer.

Project description:Background: MiR-196a2 rs11614913 polymorphism has been studied in a wide range of cancers throughout the years. Despite a large number of epidemiological studies performed in almost all ethnic populations, the contribution of this polymorphism to cancer risk is still inconclusive. Therefore, this updated meta-analysis was performed to estimate a meticulous correlation between miR-196a2 rs11614913 variant and cancer susceptibility. Methods: A systematic study search was carried out using PubMed, ScienceDirect, CNKI, EMBASE, Scopus, and Google Scholar databases following PRISMA guidelines to find necessary literature up to December 15, 2021. Pooled odds ratios with corresponding 95% confidence intervals were estimated using RevMan 5.4 based on ethnicities, cancer types, control sources, and genotyping methods. Results: A total of 152 studies, including 120 135 subjects (53 818 patients and 66 317 controls; 140 studies, after removing studies that deviated from HWE: 51 459 cases and 62 588 controls), were included in this meta-analysis. Quantitative synthesis suggests that the miR-196a2 rs11614913 genetic variant is significantly correlated with the reduced risk of overall cancer in CDM2, CDM3, RM, and AM (odds ratio < 1 and P < .05). It is also observed from ethnicity-based subgroup analysis that rs11614913 polymorphism is significantly (P < .05) linked with cancer in the Asian (in CDM2, CDM3, RM, AM) and the African population (in CDM1, CDM3, ODM). Stratified analysis based on the cancer types demonstrated a significantly decreased correlation for breast, hepatocellular, lung, and gynecological cancer and an increased association for oral and renal cell cancer. Again, the control population-based subgroup analysis reported a strongly reduced correlation for HB population in CDM2, RM, and AM. A substantially decreased risk was also observed for other genotyping methods in multiple genetic models. Conclusions: MiR-196a2 rs11614913 variant is significantly correlated with overall cancer susceptibility. Besides, rs11614913 is correlated with cancer in Asians and Africans. It is also correlated with breast, gynecological, hepatocellular, lung, oral, and renal cell cancer.

Dataset Information

MiR-196a2 polymorphisms and susceptibility to cancer: A meta-analysis involving 24,697 subjects.

Publications

miR-196a2 polymorphisms and susceptibility to cancer: A meta-analysis involving 24,697 subjects.

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