Dataset Information

An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts.

ABSTRACT:

Background

Rotaviruses are the single most important cause of severe diarrhea in young children worldwide. The developments of specific, potent and accessible antiviral treatments that restrain rotavirus infection remain important to control rotavirus disease.

Methods

150 plant extracts with nutritional applications were screened in vitro on MA-104 cells for their antiviral activity against rhesus rotavirus (RRV). One extract (Aspalathus linearis (Burm.f.) R.Dahlgren) was also tested for its effect on the loss of transepithelial resistance (TER) of Caco-2 cells caused by simian rotavirus (SA-11) infection.

Results

Aqueous extracts of Nelumbo nucifera Gaertn. fruit, Urtica dioica L. root, Aspalathus linearis (Burm.f.) R.Dahlgren leaves, Glycyrrhiza glabra L. root and Olea europaea L. leaves were found to have strong significant antiviral activity with a 50% inhibitory concentration (IC50)?ConclusionsThese results indicate that nutritional intervention with extracts of Nelumbo nucifera Gaertn., Aspalathus linearis (Burm.f.) R.Dahlgren, Urtica dioica L., Glycyrrhiza glabra L. and Olea europaea L. might be useful in the treatment of diarrhea caused by rotavirus infection.

SUBMITTER: Knipping K

PROVIDER: S-EPMC3439294 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Publications

An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts.

Knipping Karen K Garssen Johan J van't Land Belinda B

Virology journal 20120726

<h4>Background</h4>Rotaviruses are the single most important cause of severe diarrhea in young children worldwide. The developments of specific, potent and accessible antiviral treatments that restrain rotavirus infection remain important to control rotavirus disease.<h4>Methods</h4>150 plant extracts with nutritional applications were screened in vitro on MA-104 cells for their antiviral activity against rhesus rotavirus (RRV). One extract (Aspalathus linearis (Burm.f.) R.Dahlgren) was also tes ...[more]

PMID: 22834653

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Dataset Information

An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts.

Background

Methods

Results

Publications

An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts.

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