Dataset Information
Interactions among vascular-tone modulators contribute to high altitude pulmonary edema and augmented vasoreactivity in highlanders.
Ontology highlight
ABSTRACT: Background
The interactions among various biomarkers remained unexplored under the stressful environment of high-altitude. Present study evaluated interactions among biomarkers to study susceptibility for high altitude pulmonary edema (HAPE) in HAPE-patients (HAPE-p) and adaptation in highland natives (HLs); both in comparison to HAPE-free sojourners (HAPE-f).Methodology/principal findings
All the subjects were recruited at 3500 m. We measured clinical parameters, biochemical levels in plasma and gene expression using RNA from blood; analyzed various correlations between and among the clinical parameters, especially arterial oxygen saturation (SaO(2)) and mean arterial pressure (MAP) and biochemical parameters like, asymmetric dimethylarginine (ADMA), serotonin (5-HT), 8-iso-prostaglandin F2? (8-isoPGF2?), endothelin-1 (ET-1), plasma renin activity (PRA), plasma aldosterone concentration (PAC), superoxide dismutase (SOD) and nitric oxide (NO) in HAPE-p, HAPE-f and HLs. ADMA, 5-HT, 8-isoPGF2?, ET-1 levels, and PAC were significantly higher (p<0.0001, each), whereas SOD activity and NO level were significantly lower in HAPE-p than HAPE-f (p ? 0.001). Furthermore, ADMA, 5-HT, 8-isoPGF2?, NO levels and PAC were significantly higher (p<0.0001), whereas ET-1 level significantly (p<0.0001) and SOD activity non-significantly (p>0.05) lower in HLs than HAPE-f. The expression of respective genes differed in the three groups. In the correlations, SaO(2) inversely correlated with ADMA, 5-HT and 8-isoPGF2? and positively with SOD in HAPE-p (p?0.009). MAP correlated positively with 5-HT and 8-isoPGF2? in HAPE-p and HLs (p ? 0.004). A strong positive correlation was observed between ADMA and 5-HT, 5-HT and 8-isoPGF2? (p?0.001), whereas inverse correlation of SOD with ET-1 in HAPE-p and HLs (p ? 0.004), with 5-HT and 8-isoPGF2? in HAPE-p (p = 0.01) and with 5-HT in HLs (p = 0.05).Conclusions/significance
The interactions among these markers confer enhanced vascular activity in HLs and HAPE in sojourners.
SUBMITTER: Ali Z
PROVIDER: S-EPMC3439466 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Interactions among vascular-tone modulators contribute to high altitude pulmonary edema and augmented vasoreactivity in highlanders.
PloS one 20120911 9
<h4>Background</h4>The interactions among various biomarkers remained unexplored under the stressful environment of high-altitude. Present study evaluated interactions among biomarkers to study susceptibility for high altitude pulmonary edema (HAPE) in HAPE-patients (HAPE-p) and adaptation in highland natives (HLs); both in comparison to HAPE-free sojourners (HAPE-f).<h4>Methodology/principal findings</h4>All the subjects were recruited at 3500 m. We measured clinical parameters, biochemical lev ...[more]
