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Plasma fluorescent oxidation products and short-term occupational particulate exposures.


ABSTRACT: Evidence suggests that fine particulate air pollution results in oxidative induced tissue damage.A global fluorescent oxidation products (FLOx) assay (fluorescent intensity (FI) units per milliliter of plasma) was measured in blood samples collected from 236 nonsmoking, Caucasian, male trucking industry workers either prior to, during, or after their work shifts. Occupational exposures to particulate matter (PM)(2.5) were based on job-specific area-level sampling. Generalized linear models were used to determine associations between FLOx levels and PM(2.5) , adjusted for age, time since last meal, alcohol consumption, aspirin, and cholesterol medications.The mean (standard deviation) level of FLOx was 265.9 FI/ml (96.0). Levels of FLOx were higher among older individuals and lower among those who had consumed alcohol in the past 24 hr. However, no associations were observed between FLOx and PM(2.5) .Our results indicate no association between occupational PM(2.5) exposure and this marker of global oxidative stress.

SUBMITTER: Hart JE 

PROVIDER: S-EPMC3439587 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Plasma fluorescent oxidation products and short-term occupational particulate exposures.

Hart Jaime E JE   Wu Tianying T   Laden Francine F   Garshick Eric E  

American journal of industrial medicine 20120522 10


<h4>Background</h4>Evidence suggests that fine particulate air pollution results in oxidative induced tissue damage.<h4>Methods</h4>A global fluorescent oxidation products (FLOx) assay (fluorescent intensity (FI) units per milliliter of plasma) was measured in blood samples collected from 236 nonsmoking, Caucasian, male trucking industry workers either prior to, during, or after their work shifts. Occupational exposures to particulate matter (PM)(2.5) were based on job-specific area-level sampli  ...[more]

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