Ontology highlight
ABSTRACT:
SUBMITTER: Roberts GA
PROVIDER: S-EPMC3439906 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Roberts Gareth A GA Stephanou Augoustinos S AS Kanwar Nisha N Dawson Angela A Cooper Laurie P LP Chen Kai K Nutley Margaret M Cooper Alan A Blakely Garry W GW Dryden David T F DT
Nucleic acids research 20120607 16
DNA mimic proteins have evolved to control DNA-binding proteins by competing with the target DNA for binding to the protein. The Ocr protein of bacteriophage T7 is the most studied DNA mimic and functions to block the DNA-binding groove of Type I DNA restriction/modification enzymes. This binding prevents the enzyme from cleaving invading phage DNA. Each 116 amino acid monomer of the Ocr dimer has an unusual amino acid composition with 34 negatively charged side chains but only 6 positively char ...[more]