MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets.
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ABSTRACT:
SUBMITTER: Shao Z
PROVIDER: S-EPMC3439967 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets.
Shao Zhen Z Zhang Yijing Y Yuan Guo-Cheng GC Orkin Stuart H SH Waxman David J DJ
Genome biology 20120316 3
ChIP-Seq is widely used to characterize genome-wide binding patterns of transcription factors and other chromatin-associated proteins. Although comparison of ChIP-Seq data sets is critical for understanding cell type-dependent and cell state-specific binding, and thus the study of cell-specific gene regulation, few quantitative approaches have been developed. Here, we present a simple and effective method, MAnorm, for quantitative comparison of ChIP-Seq data sets describing transcription factor ...[more]
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