Ontology highlight
ABSTRACT:
SUBMITTER: Fields AJ
PROVIDER: S-EPMC3440513 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Fields Aaron J AJ Nawathe Shashank S Eswaran Senthil K SK Jekir Michael G MG Adams Mark F MF Papadopoulos Panayiotis P Keaveny Tony M TM
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20121001 10
The mechanisms of age-related vertebral fragility remain unclear, but may be related to the degree of "structural redundancy" of the vertebra; ie, its ability to safely redistribute stress internally after local trabecular failure from an isolated mechanical overload. To better understand this issue, we performed biomechanical testing and nonlinear micro-CT-based finite element analysis on 12 elderly human thoracic ninth vertebral bodies (age 76.9 ± 10.8 years). After experimentally overloading ...[more]