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Vertebral fragility and structural redundancy.


ABSTRACT: The mechanisms of age-related vertebral fragility remain unclear, but may be related to the degree of "structural redundancy" of the vertebra; ie, its ability to safely redistribute stress internally after local trabecular failure from an isolated mechanical overload. To better understand this issue, we performed biomechanical testing and nonlinear micro-CT-based finite element analysis on 12 elderly human thoracic ninth vertebral bodies (age 76.9?±?10.8 years). After experimentally overloading the vertebrae to measure strength, we used nonlinear finite element analysis to estimate the amount of failed tissue and understand the failure mechanisms. We found that the amount of failed tissue per unit bone mass decreased with decreasing bone volume fraction (r(2) ?=?0.66, p?

SUBMITTER: Fields AJ 

PROVIDER: S-EPMC3440513 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Vertebral fragility and structural redundancy.

Fields Aaron J AJ   Nawathe Shashank S   Eswaran Senthil K SK   Jekir Michael G MG   Adams Mark F MF   Papadopoulos Panayiotis P   Keaveny Tony M TM  

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20121001 10


The mechanisms of age-related vertebral fragility remain unclear, but may be related to the degree of "structural redundancy" of the vertebra; ie, its ability to safely redistribute stress internally after local trabecular failure from an isolated mechanical overload. To better understand this issue, we performed biomechanical testing and nonlinear micro-CT-based finite element analysis on 12 elderly human thoracic ninth vertebral bodies (age 76.9 ± 10.8 years). After experimentally overloading  ...[more]

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