Dataset Information

Lack of evidence to support the association of polymorphisms within the TNFSF4 gene and coronary heart disease in a Chinese Han population.

ABSTRACT: Coronary heart disease (CHD) is a complex disorder resulting from the interaction of a number of genetic and environmental factors. Increasing evidence has shown that OX40 ligand (OX40L), also known as tumor necrosis factor superfamily member 4 (TNFSF4), plays a key role in the pathogenesis of atherosclerosis. However, there have been inconsistent reports in various populations, and further studies are required to clarify this issue. A gene-based association study was conducted using five single-nucleotide polymorphisms (SNPs) reported in previous studies. The five SNPs (rs1234314, rs45454293, rs3850641, rs1234313 and rs3861950) were genotyped in 547 unrelated CHD patients and 601 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism. rs1234314, rs3850641 and rs3861950 were further genotyped in an additional 512 cases and 520 controls using the TaqMan SNP genotyping method. A possible relationship between the five SNPs and the severity of CHD was investigated. The results revealed no significant association between the TNFSF4 polymorphism and CHD. In addition, the stratified analysis of genotypic and allelic frequencies showed no association between the TNFSF4 polymorphism and CHD in either gender. Finally, no significant correlation between the TNFSF4 polymorphism and CHD severity was detected. These findings do not support a role of the TNFSF4 gene in CHD pathogenesis in the Chinese Han population.

SUBMITTER: Cheng G

PROVIDER: S-EPMC3440652 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Lack of evidence to support the association of polymorphisms within the TNFSF4 gene and coronary heart disease in a Chinese Han population.

Cheng Guanghui G Wang Hui H Chen Minzhi M Li Li L Gong Yaoqin Y Liu Qiji Q

Experimental and therapeutic medicine 20101216 2

Coronary heart disease (CHD) is a complex disorder resulting from the interaction of a number of genetic and environmental factors. Increasing evidence has shown that OX40 ligand (OX40L), also known as tumor necrosis factor superfamily member 4 (TNFSF4), plays a key role in the pathogenesis of atherosclerosis. However, there have been inconsistent reports in various populations, and further studies are required to clarify this issue. A gene-based association study was conducted using five single ...[more]

PMID: 22977497

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Project description:There is a strong link between heart disease and depression, both of which are closely related to lifetime stress exposure. Serum/glucocorticoid-regulated kinase 1 (SGK1) is a stress-responsive gene with a pivotal role in both the heart and brain. To determine the role of SGK1 polymorphisms (rs2758151, rs1743963, rs9493857, rs1763509, rs9376026, and rs9389154) in susceptibility to comorbid coronary heart disease (CHD) and depression, we conducted a hospital-based case-control study involving 257 CHD cases (including 69 cases with depression and 188 cases without depression) and 107 controls in a Chinese Han population. Six single-nucleotide polymorphisms (SNPs) in the SGK1 gene were successfully genotyped by polymerase chain reaction-ligase detection reaction (PCR-LDR) assay. Our results showed no significant differences in SGK1 genetic polymorphisms between CHD patients and controls, whereas significant associations were observed between SGK1 SNPs (rs1743963 and rs1763509) and the development of depression in CHD patients (P = 0.018 by genotype, P = 0.032 by allele; P = 0.017 by genotype, P = 0.003 by allele, respectively). However, none of these associations remained significant after Bonferroni correction (P = 0.054 for rs1743963; P = 0.051 for rs1763509). Interestingly, both the GG genotype of SGK1 rs1743963 and AA genotype of SGK1 rs1763509 were associated with a higher risk of depression in CHD patients; for rs1763509, the Patient Health Questionnaire-9 (PHQ-9) scores in the carriers of the risk genotype for comorbid depression, AA, were significantly higher than in GG and AG carriers (P = 0.008). Notably, haplotype analysis indicated that haplotype GGA significantly increased the risk of depression in CHD patients (P = 0.011, odds ratio (OR) = 1.717, 95% confidence interval (CI) = 1.132-2.605), whereas haplotype AAG may be a protective factor for CHD patients with comorbid depression (P = 0.038, OR = 0.546, 95% CI = 0.307-0.972). It should be noted that only the significance of haplotype GGA survived after Bonferroni adjustment (P = 0.044) and that no significant differences were found for other SGK1 SNPs (rs2758151, rs9493857, rs9376026, and rs9389154) between CHD patients with and without depression. These findings, for the first time, elucidate the important role of SGK1 variants in the comorbidity of CHD and depression.

Dataset Information

Lack of evidence to support the association of polymorphisms within the TNFSF4 gene and coronary heart disease in a Chinese Han population.

Publications

Lack of evidence to support the association of polymorphisms within the TNFSF4 gene and coronary heart disease in a Chinese Han population.

Similar Datasets

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