Ontology highlight
ABSTRACT:
SUBMITTER: Pope BD
PROVIDER: S-EPMC3441118 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Pope Benjamin D BD Chandra Tamir T Buckley Quinton Q Hoare Matthew M Ryba Tyrone T Wiseman Frances K FK Kuta Anna A Wilson Michael D MD Odom Duncan T DT Gilbert David M DM
Human molecular genetics 20120626 19
In multicellular organisms, developmental changes to replication timing occur in 400-800 kb domains across half the genome. While examples of epigenetic control of replication timing have been described, a role for DNA sequence in mammalian replication-timing regulation has not been substantiated. To assess the role of DNA sequences in directing developmental changes to replication timing, we profiled replication timing in mice carrying a genetically rearranged Human Chromosome 21 (Hsa21). In tw ...[more]