Ontology highlight
ABSTRACT:
SUBMITTER: Mondal K
PROVIDER: S-EPMC3441129 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Mondal Kajari K Ramachandran Dhanya D Patel Viren C VC Hagen Katie R KR Bose Promita P Cutler David J DJ Zwick Michael E ME
Human molecular genetics 20120705 19
Autism spectrum disorder (ASD) is a heterogeneous disorder with substantial heritability, most of which is unexplained. ASD has a population prevalence of one percent and affects four times as many males as females. Patients with fragile X E (FRAXE) intellectual disability, which is caused by a silencing of the X-linked gene AFF2, display a number of ASD-like phenotypes. Duplications and deletions at the AFF2 locus have also been reported in cases with moderate intellectual disability and ASD. W ...[more]