Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.
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ABSTRACT:
SUBMITTER: Reikie BA
PROVIDER: S-EPMC3441420 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.
Reikie Brian A BA Adams Rozanne C M RC Ruck Candice E CE Ho Kevin K Leligdowicz Aleksandra A Pillay Santoshan S Naidoo Shalena S Fortuno Edgardo S ES de Beer Corena C Preiser Wolfgang W Cotton Mark F MF Speert David P DP Esser Monika M Kollmann Tobias R TR
PloS one 20120913 9
The first year of life represents a time of marked susceptibility to infections; this is particularly true for regions in sub-Saharan Africa. As innate immunity directs the adaptive immune response, the observed increased risk for infection as well as a suboptimal response to vaccination in early life may be due to less effective innate immune function. In this study, we followed a longitudinal cohort of infants born and raised in South Africa over the first year of life, employing the most comp ...[more]
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