Ontology highlight
ABSTRACT:
SUBMITTER: Harrison H
PROVIDER: S-EPMC3442245 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Harrison Hannah H Farnie Gillian G Howell Sacha J SJ Rock Rebecca E RE Stylianou Spyros S Brennan Keith R KR Bundred Nigel J NJ Clarke Robert B RB
Cancer research 20100112 2
Notch receptor signaling pathways play an important role not only in normal breast development but also in breast cancer development and progression. We assessed the role of Notch receptors in stem cell activity in breast cancer cell lines and nine primary human tumor samples. Stem cells were enriched by selection of anoikis-resistant cells or cells expressing the membrane phenotype ESA(+)/CD44(+)/CD24(low). Using these breast cancer stem cell populations, we compared the activation status of No ...[more]