Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC3442268 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Wang Wei W Zhu John Z JZ Chang Karen T KT Min Kyung-Tai KT
The EMBO journal 20120803 18
Most common genetic factors known to cause intellectual disability are Down syndrome and Fragile X syndrome. However, the underlying cellular and molecular mechanisms of intellectual disability remain unclear. Recently, dendritic spine dysmorphogenesis and impaired local protein synthesis are posited to contribute to the cellular mechanisms of intellectual disability. Here, we show that Down syndrome critical region1 (DSCR1) interacts with Fragile X mental retardation protein (FMRP) and regulate ...[more]