Ontology highlight
ABSTRACT:
SUBMITTER: Soto-Rifo R
PROVIDER: S-EPMC3442272 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Soto-Rifo Ricardo R Rubilar Paulina S PS Limousin Taran T de Breyne Sylvain S Décimo Didier D Ohlmann Théophile T
The EMBO journal 20120807 18
Here, we have characterized a step in translation initiation of viral and cellular mRNAs that contain RNA secondary structures immediately at the vicinity of their m(7)GTP cap. This is mediated by the DEAD-box helicase DDX3 which can directly bind to the 5' of the target mRNA where it clamps the entry of eIF4F through an eIF4G and Poly A-binding protein cytoplasmic 1 (PABP) double interaction. This could induce limited local strand separation of the secondary structure to allow 43S pre-initiatio ...[more]