Ontology highlight
ABSTRACT:
SUBMITTER: Huang Z
PROVIDER: S-EPMC3442290 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Huang Zhenhua Z Hurley Paula J PJ Simons Brian W BW Marchionni Luigi L Berman David M DM Ross Ashley E AE Schaeffer Edward M EM
Oncotarget 20120601 6
Prostate cancer is one of the most common malignancies and the second leading cause of death from cancer in men. The molecular mechanisms driving prostate carcinogenesis are complex; with several lines of evidence suggesting that the reexpression of conserved developmental programs plays a key role. In this study, we used conditional gene targeting and organ grafting, to describe conserved roles for the transcription factor Sox9 in the initiation of both prostate organogenesis and prostate carci ...[more]