Ontology highlight
ABSTRACT:
SUBMITTER: Athanasiou D
PROVIDER: S-EPMC3442401 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Athanasiou Dimitra D Kosmaoglou Maria M Kanuga Naheed N Novoselov Sergey S SS Paton Adrienne W AW Paton James C JC Chapple J Paul JP Cheetham Michael E ME
Molecular biology of the cell 20120801 18
Mutations in rod opsin-the light-sensitive protein of rod cells-cause retinitis pigmentosa. Many rod opsin mutations lead to protein misfolding, and therefore it is important to understand the role of molecular chaperones in rod opsin biogenesis. We show that BiP (HSPA5) prevents the aggregation of rod opsin. Cleavage of BiP with the subtilase cytotoxin SubAB results in endoplasmic reticulum (ER) retention and ubiquitylation of wild-type (WT) rod opsin (WT-green fluorescent protein [GFP]) at the ...[more]