Ontology highlight
ABSTRACT:
SUBMITTER: Chen KR
PROVIDER: S-EPMC3442552 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Chen Kuan-Ru KR Chang Chun-Hung CH Huang Ching-Yu CY Lin Chun-Yang CY Lin Wan-Ying WY Lo Yin-Chiu YC Yang Chia-Yu CY Hsing En-Wei EW Chen Lin-Fang LF Shih Shin-Ru SR Shiau Ai-Li AL Lei Huan-Yao HY Tan Tse-Hua TH Ling Pin P
The Journal of biological chemistry 20120725 38
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key RNA viral sensors for triggering antiviral immunity. The underlying mechanisms for RLRs to trigger antiviral immunity have yet to be explored. Here we report the identification of TAPE (TBK1-associated protein in endolysosomes) as a novel regulator of the RLR pathways. TAPE functionally and physically interacts with RIG-I, MDA5, and IPS-1 to activate the IFN-β promoter. TAPE knockdown impairs IFN-β activation induced by RLRs bu ...[more]