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Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens.

ABSTRACT: Glycolipids presented by the major histocompatibility complex (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by either a semi-invariant T cell antigen receptor (TCR) repertoire (type I NKT cells or iNKT cells) or a relatively variable TCR repertoire (type II NKT cells). Here we describe the structure of a type II NKT cell TCR in complex with CD1d-lysosulfatide. Both TCR ?-chains and TCR ?-chains made contact with the CD1d molecule with a diagonal footprint, typical of MHC-TCR interactions, whereas the antigen was recognized exclusively with a single TCR chain, similar to the iNKT cell TCR. Type II NKT cell TCRs, therefore, recognize CD1d-sulfatide complexes by a distinct recognition mechanism characterized by the TCR-binding features of both iNKT cells and conventional peptide-reactive T cells.

SUBMITTER: Girardi E 

PROVIDER: S-EPMC3442777 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens.

Girardi Enrico E   Maricic Igor I   Wang Jing J   Mac Thien-Thi TT   Iyer Pooja P   Kumar Vipin V   Zajonc Dirk M DM  

Nature immunology 20120722 9

Glycolipids presented by the major histocompatibility complex (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by either a semi-invariant T cell antigen receptor (TCR) repertoire (type I NKT cells or iNKT cells) or a relatively variable TCR repertoire (type II NKT cells). Here we describe the structure of a type II NKT cell TCR in complex with CD1d-lysosulfatide. Both TCR α-chains and TCR β-chains made contact with the CD1d molecule with a diagonal fo  ...[more]