Ontology highlight
ABSTRACT:
SUBMITTER: Quevillon-Cheruel S
PROVIDER: S-EPMC3443122 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Quevillon-Cheruel Sophie S Campo Nathalie N Mirouze Nicolas N Mortier-Barrière Isabelle I Brooks Mark A MA Boudes Marion M Durand Dominique D Soulet Anne-Lise AL Lisboa Johnny J Noirot Philippe P Martin Bernard B van Tilbeurgh Herman H Noirot-Gros Marie-Françoise MF Claverys Jean-Pierre JP Polard Patrice P
Proceedings of the National Academy of Sciences of the United States of America 20120817 37
Transformation promotes genome plasticity in bacteria via RecA-driven homologous recombination. In the gram-positive human pathogen Streptococcus pneumoniae, the transformasome a multiprotein complex, internalizes, protects, and processes transforming DNA to generate chromosomal recombinants. Double-stranded DNA is internalized as single strands, onto which the transformation-dedicated DNA processing protein A (DprA) ensures the loading of RecA to form presynaptic filaments. We report that the s ...[more]