Human blood metabolite timetable indicates internal body time.
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ABSTRACT:
SUBMITTER: Kasukawa T
PROVIDER: S-EPMC3443163 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
Human blood metabolite timetable indicates internal body time.
Kasukawa Takeya T Sugimoto Masahiro M Hida Akiko A Minami Yoichi Y Mori Masayo M Honma Sato S Honma Ken-ichi K Mishima Kazuo K Soga Tomoyoshi T Ueda Hiroki R HR
Proceedings of the National Academy of Sciences of the United States of America 20120827 37
A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information to maximize potency and minimize toxicity during drug administration and feeding, respectively. Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood to estimate internal body time from samples taken at only a few time points. Here we applied this molecular-timetable concept to ...[more]
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2020-10-12 | GSE134703 | GEO