Dataset Information

Effectiveness of two new types of sealants: retention after 2 years.

ABSTRACT: The hypotheses tested were: survival rate of fully and partially retained glass-carbomer sealants is higher than those of high-viscosity glass-ionomer, with and without energy supplied, and that of resin composite; survival rate of fully and partially retained sealants of high-viscosity glass-ionomer with energy supplied is higher than those without energy supplied. The randomized clinical trial covered 407 children, with a mean age of 8 years. The evaluation took place after 0.5, 1 and 2 years. Survival of sealant material in occlusal and in smooth surfaces, using the traditional categorization (fully and partially retained versus completely lost sealants) and the modified categorization (fully and more than 2/3 of the sealant retained versus completely lost sealants), were dependent variables. The Kaplan-Meier survival method was used. According to both categorizations of partially retained sealants, the survival of completely and partially retained resin composite sealants in occlusal and in smooth tooth surfaces was statistically significantly higher, and those of glass-carbomer sealants lower, than those of sealants of the other three groups. There was no statistically significant difference in the survival rates of completely and partially retained high-viscosity glass-ionomer sealants with and without energy supplied in occlusal and in smooth surfaces. After 2 years, glass-carbomer sealant retention was the poorest, adding energy to high-viscosity glass-ionomer sealant did not increase the retention rate and resin composite sealants were retained the longest. We suggest the use of the modified categorization of partially retained sealants in future studies. It seems not necessary to cure high-viscosity glass-ionomer sealants. The use of glass-carbomer sealants cannot be recommended yet.

SUBMITTER: Chen X

PROVIDER: S-EPMC3443351 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effectiveness of two new types of sealants: retention after 2 years.

Chen Xi X Du Minquan M Fan Mingwen M Mulder Jan J Huysmans Marie-Charlotte MC Frencken Jo E JE

Clinical oral investigations 20111129 5

The hypotheses tested were: survival rate of fully and partially retained glass-carbomer sealants is higher than those of high-viscosity glass-ionomer, with and without energy supplied, and that of resin composite; survival rate of fully and partially retained sealants of high-viscosity glass-ionomer with energy supplied is higher than those without energy supplied. The randomized clinical trial covered 407 children, with a mean age of 8 years. The evaluation took place after 0.5, 1 and 2 years. ...[more]

PMID: 22124610

Similar Datasets

Project description:Tuberous sclerosis (TS) is a rare autosomal dominant systemic disease with an estimated prevalence of 1/6000. Renal angiomyolipoma (AML) is a benign tumour with high morbidity frequently present in TS. The aim of the study was to test the effect of rapamycin in reducing the volume of AML in TS.Twenty four-month prospective open-label, single arm, unicentre Phases II andIII study. The primary endpoint was to evaluate the effect of treatment on the reduction of at least 50% AML volume from baseline at 24 months. The secondary endpoints were: average tumour reduction, surgical complications, skin lesions and drug safety.The study population comprised 17 patients, aged >10 years who were diagnosed with TS and had ?1 renal AML >2 cm of diameter and had a serum creatinine < 2mg/dl and urine protein/creatinine ratio < 22.6 mg/mmol. The trial was conducted at Fundació Puigvert. Rapamycin was given to achieve stable plasma levels between 4 and 8 ng/ml. AML volume was estimated using orthogonal measurements by MRI at baseline, 6, 12 and 24 months.Ten out of 17 patients were success responders for the main outcome -58.8%, 95%CI: 32.9% to 81.6%-. After 6 months of therapy, the mean volume decrease was 55.18% (5.01 standard error (SE); p<0.001) and 66.38% (4.41 SE; p<0.001) at year 1. There was no significant decrease between year 1 and 2. According to RECIST criteria, all patients achieved a partial response at year 1 and all but two had already achieved this partial response after 6 months.The main analysis was performed according to the intention-to-treat principle analysis. Tumour volume was analyzed over time by means of mixed models for repeated measurement analysis. We used the baseline tumour volume as a covariate for the absolute change and percentage change from baseline data. The analysis was performed using SAS version 9.2 software, and the level of significance was established at 0.05 (two-sided).This study show that mTOR inhibitors are a relatively safe, efficacious and less aggressive alternative than currently available options in the management of AML in TS.EudraCT number: 2007-005978-30, ClinicalTrials.gov number: NCT0121712.

Dataset Information

Effectiveness of two new types of sealants: retention after 2 years.

Publications

Effectiveness of two new types of sealants: retention after 2 years.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets