Ontology highlight
ABSTRACT:
SUBMITTER: Unwin N
PROVIDER: S-EPMC3443390 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Unwin Nigel N Fujiyoshi Yoshinori Y
Journal of molecular biology 20120724 5
The nicotinic acetylcholine (ACh) receptor converts transiently to an open-channel form when activated by ACh released into the synaptic cleft. We describe here the conformational change underlying this event, determined by electron microscopy of ACh-sprayed and freeze-trapped postsynaptic membranes. ACh binding to the α subunits triggers a concerted rearrangement in the ligand-binding domain, involving an ~1-Å outward displacement of the extracellular portion of the β subunit where it interacts ...[more]