Ontology highlight
ABSTRACT:
SUBMITTER: Singh M
PROVIDER: S-EPMC3443509 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Singh Mamata M Martinez Alaina R AR Govindaraju Suman S Lee Beth S BS
Journal of cellular physiology 20130101 1
Human antigen R (HuR) is a post-transcriptional regulator of gene expression that plays a key role in stabilizing mRNAs during cellular stress, leading to enhanced survival. HuR expression is tightly regulated through multiple transcription and post-transcriptional controls. Although HuR is known to stabilize a subset of mRNAs involved in cell survival, its role in the survival pathway of PI3-kinase/Akt signaling is unclear. Here, we show that in renal proximal tubule cells, HuR performs a centr ...[more]