Ontology highlight
ABSTRACT:
SUBMITTER: Mandelbaum AD
PROVIDER: S-EPMC3443614 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Experimental diabetes research 20120906
microRNAs (miRNAs) play important roles in pancreas development and in regulation of insulin expression in the adult. Here we show that loss of miRNAs activity in beta-cells during embryonic development results in lower beta-cell mass and in impaired glucose tolerance. Dicer1-null cells initially constitute a significant portion of the total beta-cell population. However, during postnatal development, Dicer1-null cells are depleted. Furthermore, wild-type beta cells are repopulating the islets i ...[more]