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Compositional control of higher order assembly using synthetic collagen peptides.

ABSTRACT: We present the case of a two-component collagen peptide hydrogel that self-assembles through noncovalent electrostatic interactions. Natural collagen materials, such as those of connective tissue or the basement membrane, assemble in a hierarchic fashion. Similarly, the synthetic peptides presented here proceed from monomer to trimer to fiber and, finally, to a hydrogel. By varying stoichiometry and concentration, we are able to dissect the stages of higher order assembly. Insight gained from this study will improve the molecular design of biomimetic materials.

SUBMITTER: Xu F

PROVIDER: S-EPMC3443862 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Compositional control of higher order assembly using synthetic collagen peptides.

Xu Fei F Li Ji J Jain Vikas V Tu Raymond S RS Huang Qingrong Q Nanda Vikas V

Journal of the American Chemical Society 20111221 1

We present the case of a two-component collagen peptide hydrogel that self-assembles through noncovalent electrostatic interactions. Natural collagen materials, such as those of connective tissue or the basement membrane, assemble in a hierarchic fashion. Similarly, the synthetic peptides presented here proceed from monomer to trimer to fiber and, finally, to a hydrogel. By varying stoichiometry and concentration, we are able to dissect the stages of higher order assembly. Insight gained from th ...[more]

PMID: 22171825

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