Ontology highlight
ABSTRACT:
SUBMITTER: Negahdar M
PROVIDER: S-EPMC3444650 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Negahdar Maria M Aukrust Ingvild I Johansson Bente B BB Molnes Janne J Molven Anders A Matschinsky Franz M FM Søvik Oddmund O Kulkarni Rohit N RN Flatmark Torgeir T Njølstad Pål Rasmus PR Bjørkhaug Lise L
Biochimica et biophysica acta 20120720 11
GCK-MODY, dominantly inherited mild fasting hyperglycemia, has been associated with >600 different mutations in the glucokinase (GK)-encoding gene (GCK). When expressed as recombinant pancreatic proteins, some mutations result in enzymes with normal/near-normal catalytic properties. The molecular mechanism(s) of GCK-MODY due to these mutations has remained elusive. Here, we aimed to explore the molecular mechanisms for two such catalytically 'normal' GCK mutations (S263P and G264S) in the F260-L ...[more]