Ontology highlight
ABSTRACT:
SUBMITTER: Holbrook LM
PROVIDER: S-EPMC3444690 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Holbrook L-M LM Sasikumar P P Stanley R G RG Simmonds A D AD Bicknell A B AB Gibbins J M JM
Journal of thrombosis and haemostasis : JTH 20120201 2
<h4>Background</h4>Thiol isomerases are a family of endoplasmic reticulum enzymes which orchestrate redox-based modifications of protein disulphide bonds. Previous studies have identified important roles for the thiol isomerases PDI and ERp5 in the regulation of normal platelet function.<h4>Aim</h4>Recently, we demonstrated the presence of a further five thiol isomerases at the platelet surface. In this report we aim to report the role of one of these enzymes - ERp57 in the regulation of platele ...[more]