Dataset Information

Excess body mass index and risk of liver cancer: a nonlinear dose-response meta-analysis of prospective studies.

ABSTRACT:

Background

Excess body weight measured as body mass index (BMI) has a positive association with risk of common cancers. However, previous meta-analyses related to BMI and liver cancer had inconsistent results. The purpose of the current study is to establish a nonlinear dose-response relationship between BMI and incidence risk of liver cancer.

Methods

A systematic literature search for relevant articles published from 1966 to November 2011 was conducted in PUBMED and EMBASE digital databases. Additional articles were manually searched by using the reference lists of identified papers. Restricted cubic splines and generalized least-squares regression methods were used to model a potential curvilinear relationship and to make a dose-response meta-analysis. Stratified analysis, sensitivity analysis and assessment of bias were performed in our meta-analysis.

Results

8 articles including 1,779,471 cohort individuals were brought into meta-analysis. A non-linear dose-response association between BMI and risk of liver cancer was visually significant (P for nonlinearity<0.001), besides, the point value of BMI also enhanced the results quantitatively, where relative risks were 1.02 (95%CI?=?1.02-1.03), 1.35 (95%CI?=?1.24-1.47) and 2.22-fold (95%CI?=?1.74-2.83) when BMI was at the point of 25, 30 and 35 kg/m(2) compared with reference (the median value of the lowest category), respectively. The ethnicity of the population was found as the main source of heterogeneity. In subsequent stratified analysis, no evidence of heterogeneity was showed in Asian and White populations (P for heterogeneity>0.1), and all value of BMI still presented significantly increased risk of cancer.

Conclusions

The findings from meta-analysis provided that excess BMI had significant increased association with risk of liver cancer, although the biological mechanisms underlying the obesity-cancer link still need to be clarified.

SUBMITTER: Rui R

PROVIDER: S-EPMC3445525 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Publications

Excess body mass index and risk of liver cancer: a nonlinear dose-response meta-analysis of prospective studies.

Rui Rui R Lou Jiao J Zou Li L Zhong Rong R Wang Ji J Xia Ding D Wang Qi Q Li Heng H Wu Jing J Lu Xuzai X Li Chuanqi C Liu Li L Xia Jiahong J Xu Hua H

PloS one 20120918 9

<h4>Background</h4>Excess body weight measured as body mass index (BMI) has a positive association with risk of common cancers. However, previous meta-analyses related to BMI and liver cancer had inconsistent results. The purpose of the current study is to establish a nonlinear dose-response relationship between BMI and incidence risk of liver cancer.<h4>Methods</h4>A systematic literature search for relevant articles published from 1966 to November 2011 was conducted in PUBMED and EMBASE digita ...[more]

PMID: 23028553

Similar Datasets

Project description:ObjectiveTo investigate whether alcohol consumption and raised body mass index (BMI) act together to increase risk of liver disease.DesignAnalysis of data from prospective cohort studies.SettingScotland.ParticipantsData were from two of the Midspan prospective cohort studies (9559 men): "Main" study 1965-8, participants from workplaces across central belt of Scotland, population of island of Tiree, and mainland relatives, and "Collaborative" study, 1970-3, participants from 27 workplaces in Glasgow, Clydebank, and Grangemouth. Follow-up was to 31 December 2007 (median 29 years, range 0.13-42). We divided participants into nine groups based on measures of body mass index (BMI) (underweight/normal weight <25, overweight 25 to <30, and obese >or=30) and alcohol consumption (none, 1-14, and >or=15 units per week).Main outcome measuresLiver disease morbidity and mortality.Results80 (0.8%) men died with liver disease as the main cause and 146 (1.5%) with liver disease as any cause. In the Collaborative study, 196 men (3.3%) had liver disease defined by a death, admission, or cancer registration. BMI and alcohol consumption were strongly associated with liver disease mortality in analyses adjusted for other confounders (P=0.001 and P<0.0001 respectively). Drinkers of 15 or more units per week in any BMI category and obese drinkers had raised relative rates for all definitions of liver disease, compared with underweight/normal weight non-drinkers. Drinkers of 15 or more units per week had adjusted relative rates for liver disease mortality of 3.16 (95% confidence interval 1.28 to 7.8) for underweight/normal weight men, 7.01 (3.02 to 16.3) for overweight, and 18.9 (6.84 to 52.4) for obese men. The relative rate for obese men who consumed 1-14 units per week was 5.3 (1.36 to 20.7). The relative excess risk due to interaction between BMI and alcohol consumption was 5.58 (1.09 to 10.1); synergy index=2.89 (1.29 to 6.47).ConclusionsRaised BMI and alcohol consumption are both related to liver disease, with evidence of a supra-additive interaction between the two. The occurrence of both factors in the same populations should inform health promotion and public health policies.

Dataset Information

Excess body mass index and risk of liver cancer: a nonlinear dose-response meta-analysis of prospective studies.

Background

Methods

Results

Conclusions

Publications

Excess body mass index and risk of liver cancer: a nonlinear dose-response meta-analysis of prospective studies.

Similar Datasets

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