Ontology highlight
ABSTRACT:
SUBMITTER: Harvey AJ
PROVIDER: S-EPMC3445581 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Harvey Alexandra J AJ Mao Shihong S Lalancette Claudia C Krawetz Stephen A SA Brenner Carol A CA
PloS one 20120918 9
Numerous studies have focused on the transcriptional signatures that underlie the maintenance of embryonic stem cell (ESC) pluripotency. However, it remains unclear whether ESC retain transcriptional aberrations seen in in vitro cultured embryos. Here we report the first global transcriptional profile comparison between ESC generated from either in vitro cultured or in vivo derived primate embryos by microarray analysis. Genes involved in pluripotency, oxygen regulation and the cell cycle were d ...[more]