Cell elasticity determines macrophage function.
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ABSTRACT:
SUBMITTER: Patel NR
PROVIDER: S-EPMC3445606 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Cell elasticity determines macrophage function.
Patel Naimish R NR Bole Medhavi M Chen Cheng C Hardin Charles C CC Kho Alvin T AT Mih Justin J Deng Linhong L Butler James J Tschumperlin Daniel D Fredberg Jeffrey J JJ Krishnan Ramaswamy R Koziel Henry H
PloS one 20120918 9
Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central mechanism that regulates macrophage function. Using macrophages of different origins and species, we report that macrophage elasticity is a major determinant of innate macrophage function. Macrophage elasticity is modulated not only by classical biologic activators such as LPS and ...[more]
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