Ontology highlight
ABSTRACT:
SUBMITTER: Guo L
PROVIDER: S-EPMC3445736 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Guo Li L Zhang Weicheng W Guzei Ilia A IA Spencer Lara C LC Gellman Samuel H SH
Organic letters 20120508 10
An asymmetric synthesis of two new diastereomeric γ-amino acids is described. Both molecules contain a cyclohexyl ring to limit conformational flexibility about the Cα-Cβ bond; they differ in having cis vs trans stereochemistry on the ring. Residues derived from the cis γ isomer are shown to support helical secondary structures in α/γ-peptide oligomers. ...[more]