Ontology highlight
ABSTRACT:
SUBMITTER: Ostler KR
PROVIDER: S-EPMC3445765 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Ostler Kelly R KR Yang Qiwei Q Looney Timothy J TJ Zhang Li L Vasanthakumar Aparna A Tian Yufeng Y Kocherginsky Masha M Raimondi Stacey L SL DeMaio Jessica G JG Salwen Helen R HR Gu Song S Chlenski Alexandre A Naranjo Arlene A Gill Amy A Peddinti Radhika R Lahn Bruce T BT Cohn Susan L SL Godley Lucy A LA
Cancer research 20120718 18
Epigenetic changes in pediatric neuroblastoma may contribute to the aggressive pathophysiology of this disease, but little is known about the basis for such changes. In this study, we examined a role for the DNA methyltransferase DNMT3B, in particular, the truncated isoform DNMT3B7, which is generated frequently in cancer. To investigate if aberrant DNMT3B transcripts alter DNA methylation, gene expression, and phenotypic character in neuroblastoma, we measured DNMT3B expression in primary tumor ...[more]