Herpesvirus exploitation of host immune inhibitory pathways.
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ABSTRACT:
SUBMITTER: Stack G
PROVIDER: S-EPMC3446756 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Herpesvirus exploitation of host immune inhibitory pathways.
Stack Gabrielle G Stacey Maria A MA Humphreys Ian R IR
Viruses 20120803 8
Herpesviruses employ a plethora of mechanisms to circumvent clearance by host immune responses. A key feature of mammalian immune systems is the employment of regulatory pathways that limit immune responsiveness. The primary functions of these mechanisms are to control autoimmunity and limit exuberant responses to harmless antigen in mucosal surfaces. However, such pathways can be exploited by viral pathogens to enable acute infection, persistence and dissemination. Herein, we outline the curren ...[more]
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