Ontology highlight
ABSTRACT:
SUBMITTER: Severinsen K
PROVIDER: S-EPMC3447394 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Severinsen Kasper K Kraft Johan F JF Koldsø Heidi H Vinberg Katrine A KA Rothman Richard B RB Partilla John S JS Wiborg Ove O Blough Bruce B Schiøtt Birgit B Sinning Steffen S
ACS chemical neuroscience 20120610 9
The human serotonin transporter (hSERT), the human dopamine transporter (hDAT), and the human norepinephrine transporter (hNET) facilitate the active uptake of the neurotransmitters serotonin, dopamine, and norepinephrine from the synaptic cleft. Drugs of abuse such as MDMA (streetname "ecstasy") and certain 1-phenyl-piperazine (PP) analogs such as 1-(3-chlorophenyl)-piperazine (mCPP) elicit their stimulatory effect by elevating the synaptic concentration of serotonin by blocking or reversing th ...[more]