Ontology highlight
ABSTRACT:
SUBMITTER: Ehara T
PROVIDER: S-EPMC3447899 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Ehara Tatsuya T Kamei Yasutomi Y Takahashi Mayumi M Yuan Xunmei X Kanai Sayaka S Tamura Erina E Tanaka Miyako M Yamazaki Tomomi T Miura Shinji S Ezaki Osamu O Suganami Takayoshi T Okano Masaki M Ogawa Yoshihiro Y
Diabetes 20120620 10
The liver is a major organ of lipid metabolism, which is markedly changed in response to physiological nutritional demand; however, the regulation of hepatic lipogenic gene expression in early life is largely unknown. In this study, we show that expression of glycerol-3-phosphate acyltransferase 1 (GPAT1; Gpam), a rate-limiting enzyme of triglyceride biosynthesis, is regulated in the mouse liver by DNA methylation, an epigenetic modification involved in the regulation of a diverse range of biolo ...[more]