Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC3448403 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Chen Chun C Kudo Makoto M Rutaganira Florentine F Takano Hiromi H Lee Candace C Atakilit Amha A Robinett Kathryn S KS Uede Toshimitsu T Wolters Paul J PJ Shokat Kevan M KM Huang Xiaozhu X Sheppard Dean D
The Journal of clinical investigation 20120709 8
Exaggerated contraction of airway smooth muscle is the major cause of symptoms in asthma, but the mechanisms that prevent exaggerated contraction are incompletely understood. Here, we showed that integrin α9β1 on airway smooth muscle localizes the polyamine catabolizing enzyme spermidine/spermine N1-acetyltransferase (SSAT) in close proximity to the lipid kinase PIP5K1γ. As PIP5K1γ is the major source of PIP2 in airway smooth muscle and its activity is regulated by higher-order polyamines, this ...[more]