Ontology highlight
ABSTRACT:
SUBMITTER: Balzer EM
PROVIDER: S-EPMC3448771 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Balzer Eric M EM Tong Ziqiu Z Paul Colin D CD Hung Wei-Chien WC Stroka Kimberly M KM Boggs Amanda E AE Martin Stuart S SS Konstantopoulos Konstantinos K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120615 10
Cell migration on planar surfaces is driven by cycles of actin protrusion, integrin-mediated adhesion, and myosin-mediated contraction; however, this mechanism may not accurately describe movement in 3-dimensional (3D) space. By subjecting cells to restrictive 3D environments, we demonstrate that physical confinement constitutes a biophysical stimulus that alters cell morphology and suppresses mesenchymal motility in human breast carcinoma (MDA-MB-231). Dorsoventral polarity, stress fibers, and ...[more]