Ontology highlight
ABSTRACT:
SUBMITTER: Alexander KD
PROVIDER: S-EPMC3449091 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Alexander Kristen D KD Schultz Zachary D ZD
Analytical chemistry 20120821 17
Tip enhanced Raman scattering (TERS) microscopy is used to image antibody conjugated nanoparticles on intact cellular membranes. The combination of plasmonic coupling and the resultant electric field obtained from intermediate focusing of a radially polarized source gives rise to Raman images with spatial resolution below 50 nm. Finite element method calculations are used to explain the origins of the observed image resolution and spectroscopic signals. The observed Raman scattering provides inf ...[more]