Ontology highlight
ABSTRACT:
SUBMITTER: Kotsafti A
PROVIDER: S-EPMC3449193 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Kotsafti Andromachi A Farinati Fabio F Cardin Romilda R Cillo Umberto U Nitti Donato D Bortolami Marina M
BMC gastroenterology 20120828
<h4>Background</h4>Dysregulation of autophagy is important in the pathogenesis of many diseases, including cancer. Several aspects of the biological role of autophagy are however still unclear and the relationship between apoptosis and autophagy, particularly in the liver has yet to be thoroughly explored. In this study we evaluated the expression of Beclin 1 (one of the main autophagocytic agents, which bridges autophagy, apoptosis and both differentiation), and both pro- (Bad, Bax) and anti-ap ...[more]