Ontology highlight
ABSTRACT:
SUBMITTER: Henriquez B
PROVIDER: S-EPMC3449309 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Henriquez Berta B Hepp Matias M Merino Paola P Sepulveda Hugo H van Wijnen Andre J AJ Lian Jane B JB Stein Gary S GS Stein Janet L JL Montecino Martin M
Journal of cellular physiology 20111101 11
The Runx2 factor is an essential component of the regulatory mechanisms that control transcription during skeletogenesis. Runx2/p57 expression in osteoblastic cells is controlled by the P1 promoter, which is recognized by key regulators of osteoblast differentiation including homeodomain factors and Wnt- and BMP-signaling mediators. Here, we report that the transcription factor C/EBPβ up-regulates Runx2/p57 expression by directly binding to the Runx2 P1 promoter in mesenchymal, pre-osteoblastic, ...[more]