Ontology highlight
ABSTRACT:
SUBMITTER: Dou G
PROVIDER: S-EPMC3454510 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Dou Guorui G Sreekumar Parameswaran G PG Spee Christine C He Shikun S Ryan Stephen J SJ Kannan Ram R Hinton David R DR
Free radical biology & medicine 20120708 5
Endoplasmic reticulum (ER) stress is linked to several pathological conditions including age-related macular degeneration. Excessive ER stress initiates cell death cascades which are mediated, in part, through mitochondrial dysfunction. Here, we identify αB crystallin as an important regulator of ER stress-induced cell death. Retinal pigment epithelial (RPE) cells from αB crystallin (-/-) mice, and human RPE cells transfected with αB crystallin siRNA, are more vulnerable to ER stress induced by ...[more]