Autism-associated promoter variant in MET impacts functional and structural brain networks.
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ABSTRACT:
SUBMITTER: Rudie JD
PROVIDER: S-EPMC3454529 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
Autism-associated promoter variant in MET impacts functional and structural brain networks.
Rudie Jeffrey D JD Hernandez Leanna M LM Brown Jesse A JA Beck-Pancer Devora D Colich Natalie L NL Gorrindo Philip P Thompson Paul M PM Geschwind Daniel H DH Bookheimer Susan Y SY Levitt Pat P Dapretto Mirella M
Neuron 20120901 5
As genes that confer increased risk for autism spectrum disorder (ASD) are identified, a crucial next step is to determine how these risk factors impact brain structure and function and contribute to disorder heterogeneity. With three converging lines of evidence, we show that a common, functional ASD risk variant in the Met Receptor Tyrosine Kinase (MET) gene is a potent modulator of key social brain circuitry in children and adolescents with and without ASD. MET risk genotype predicted atypica ...[more]
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