Ontology highlight
ABSTRACT:
SUBMITTER: Diao J
PROVIDER: S-EPMC3457153 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Diao Jingyu J Pantua Homer H Ngu Hai H Komuves Laszlo L Diehl Lauri L Schaefer Gabriele G Kapadia Sharookh B SB
Journal of virology 20120801 20
While epidermal growth factor receptor (EGFR) has been shown to be important in the entry process for multiple viruses, including hepatitis C virus (HCV), the molecular mechanisms by which EGFR facilitates HCV entry are not well understood. Using the infectious cell culture HCV model (HCVcc), we demonstrate that the binding of HCVcc particles to human hepatocyte cells induces EGFR activation that is dependent on interactions between HCV and CD81 but not claudin 1. EGFR activation can also be ind ...[more]