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Genome sequence of a novel HIV-1 circulating recombinant form 54_01B from Malaysia.

ABSTRACT: We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B' and CRF01_AE, with identical recombination breakpoints observed in the gag, pol, and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B' and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.

SUBMITTER: Ng KT

PROVIDER: S-EPMC3457179 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Genome sequence of a novel HIV-1 circulating recombinant form 54_01B from Malaysia.

Ng Kim Tien KT Ong Lai Yee LY Takebe Yutaka Y Kamarulzaman Adeeba A Tee Kok Keng KK

Journal of virology 20121001 20

We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B' and CRF01_AE, with identical recombination breakpoints observed in the gag, pol, and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the su ...[more]

PMID: 22997423

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